What are the immediate short-term effects of methamphetamine misuse? National Institute on Drug Abuse NIDA

Heat and cold are detected by temperature sensors in the body, which are located in both the periphery and CNS. The peripheral sensors are found in the skin and utilize transient receptor potential (TRP) channels on primary sensory afferents to relay information to the CNS, and ultimately the hypothalamus (Morrison & Nakamura, 2011). Once this information reaches i drink every night am i an alcoholic the hypothalamus, warm-sensitive neurons in the anterior preoptic area respond to changes in temperature, which are sensed locally in the tissue (Nakayama et al., 1961). Bednarczyk is the chair of the University at Buffalo School of Pharmacy and Pharmaceutical Sciences. He said people of any age can experience a heart attack or stroke because of meth use.

Meth Overdose

This overstimulation manifests as symptoms of meth abuse, including hyperactivity, paranoia, and aggression. People who have been taking meth for some time have already suffered irreversible damage to their cardiovascular system that puts them at risk for death. It is a stronger form of amphetamine and a drug sometimes used legally to treat health issues such as attention deficit hyperactivity disorder (ADHD) and narcolepsy. Like other drugs that are easy to abuse, meth is known to cause an overdose.

3. Clinical consequences of METH hyperthermia

Methamphetamine causes neurotransmitter release and increased metabolism in the central nervous system (CNS). Additionally, methamphetamine can increase heart rate and result in hyperactivity, leading to increased heat production in the periphery. Vasoconstriction is another consequence of methamphetamine exposure, which results in a decreased ability of the body to rid itself of the increased heat resulting from these effects. People who use methamphetamine can face risks, including stimulant overdose or overamping. Learn more about how drug decriminalization and investing in health, harm reduction services, overdose prevention centers, and safer supply can keep people safer. Psychostimulants with abuse potential include both illicit drugs, such as methamphetamine and ecstasy, as well as prescription stimulants.

Temperature regulation

Another potential mechanism by which METH is believed to cause hyperthermia is through increases in immune responses, such as cytokine release. These effects appear to be mediated primarily through peripheral, rather than central, mechanisms. Physiological responses used to maintain body temperature are regulated by an integration of central nervous system (CNS) and systemic events, with coordination of these processes primarily controlled in the hypothalamus (Morrison & Nakamura, 2011).

Signs And Symptoms Of A Meth Overdose

Inpatient programs are typically the most expensive, costing anywhere from $5,000 to $80,000. But what you’ll pay depends on where you get treatment, how long you stay, what services you need, and your health insurance coverage. A national survey on people aged 12 or older shows that 0.6% of the U.S. population, or about 1.6 million people, may have a methamphetamine use disorder.

This website is using a security service to protect itself from online attacks. There are several actions that could trigger this block including submitting recovery national institute on drug abuse nida a certain word or phrase, a SQL command or malformed data. Doctors may administer a crystalloid intravenously to eliminate the drug through the urine.

In addition to these Mexican “superlabs,” there are many small home labs in the U. S. Making meth is a dangerous process because of the chemicals involved. Meth contains chemicals that are similar to amphetamine, a drug used to treat ADHD and narcolepsy. Find out the differences between Adderall and methamphetamines, as well as amphetamines vs. methamphetamines. People may also try to treat the difficult “crash” period of meth with depressants like alcohol.

It may be that the experience of methamphetamine “overdose” cannot be described using the same framework that is currently used to describe opioid overdose. The primary effects of opioid agonists such as heroin include analgesia, euphoria, and respiratory depression [46]. On the other hand, methamphetamine has both acute and chronic effects on the cardiovascular and cerebrovascular systems [20], and has been implicated in various underlying cardiac and cerebrovascular diseases that result in death [47].

AddictionResource fact-checks all the information before publishing and uses only credible and trusted sources when citing any medical data. The Verified badge on our articles is a trusted sign of the most comprehensive scientifically-based medical content.If you have any concern that our content is inaccurate or it should be updated, please let our team know at [email protected]. If overdose happens, the health effects are widespread and cover several body systems, especially if care is delayed.

  1. Hyperthermia can promote rhabdomyolysis, multi-organ failure, release of excitotoxic neurotransmitters, increased reactive oxygen species production, and heightened breakdown of cytoskeletal proteins (Eyer & Zilker, 2007; West et al., 2010).
  2. The only legal meth product is a prescription medication approved to treat ADHD.
  3. Dangerously high body temperature, or hyperthermia, is a common outcome of meth overdose.
  4. Any information found on RehabCenter.net should never be used to diagnose a disease or health problem, and in no way replaces or substitutes professional care.
  5. Some people go on binges, using the drug continuously for several hours or days at a time.
  6. KPS took part in conceptualization, data curation, project administration, supervision.

In contrast to dopamine receptors, the dopamine transporter (DAT) appears to play a more limited role in mediating METH-induced changes in body temperature. In particular, DAT knockout mice show a modest, albeit insignificant, reduction in METH-induced hyperthermia as compared to wild-type controls (Numachi et al., 2007). The compromised ability of METH to fully elicit hyperthermia in the absence of DAT suggests some involvement of an increase in synaptic dopamine by METH in altering body temperature, but indicate that this is most likely not the primary cause of the hyperthermic effects. DAT knockout mice do, however, have a significantly higher LD50 for METH compared to wild-type mice, supporting the importance of dopamine in the lethal effects of METH (Numachi et al., 2007).

Information on general thermoregulatory mechanisms that are affected by METH are summarized, followed by an overview of environmental factors and disease states that can modulate the effect of METH on body temperature. A much weaker form of the drug is used to treat narcolepsy alcohol misconceptions and attention deficit hyperactivity disorder (ADHD). Medicines that are legally used to treat cold symptoms, such as decongestants, can be made into methamphetamines. Other related compounds include MDMA, (‘ecstasy,’ ‘Molly,’ ‘E’), MDEA, (‘Eve’), and MDA, (‘Sally,’ ‘sass’).

In the early 2000s, the highest prevalence of methamphetamine use was in Asian Regions [2]. Since then, methamphetamine use has been expanding in other regions of the globe [3, 4]. The UN Office on Drugs and Crime has been noting increasing use of amphetamine type stimulants, particularly methamphetamine, for over a decade [2]. In 2019, an estimated 27 million persons worldwide used methamphetamine, with the highest prevalence occurring in North America [3]. Many of the drugs that have been previously shown to have no significant effects on METH-induced hyperthermia were initially tested due to their fever-reducing, anti-inflammatory, and/or neuroprotective effects.

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